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Donors with Crohn's Disease

Crohn's Disease

Crohn's disease is an inflammatory bowel disease, causing chronic symptoms such as abdominal pain, severe diarrhea, fatigue, weight loss, among others.


These factors may worsen or become mild over time. However, there is no cause for this disease. There are known possible factors such as genetic predisposition and deficiencies that influence its development.


There is no current cure for this condition, there are therapies that can reduce its signs and achieve remission and de-inflammation.



In Crohn's disease, any part of your small or large intestine can be involved. It may involve multiple segments, or it may be continuous. In some people, the disease is only in the colon, which is part of the large intestine.

Signs and symptoms of Crohn's disease can range from mild to severe. They usually develop gradually, but sometimes will come on suddenly, without warning. You may also have periods of time when you have no signs or symptoms (remission).

When the disease is active, symptoms typically include:

  • Diarrhea

  • Fever

  • Fatigue

  • Abdominal pain and cramping

  • Blood in your stool

  • Mouth sores

  • Reduced appetite and weight loss

  • Pain or drainage near or around the anus due to inflammation from a tunnel into the skin (fistula)

Risk factors for Crohn's disease may include:

  • Age. Crohn's disease can occur at any age, but you're likely to develop the condition when you're young. Most people who develop Crohn's disease are diagnosed before they're around 30 years old.

  • Ethnicity. Although Crohn's disease can affect any ethnic group, whites have the highest risk, especially people of Eastern European (Ashkenazi) Jewish descent. However, the incidence of Crohn's disease is increasing among Black people who live in North America and the United Kingdom. Crohn's disease is also being increasingly seen in the Middle Eastern population and among migrants to the United States.

  • Family history. You're at higher risk if you have a first-degree relative, such as a parent, sibling or child, with the disease. As many as 1 in 5 people with Crohn's disease has a family member with the disease.


Source:Mayo Clinic

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